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| {{Infobox Studie|Name=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study|Publikation={{Literatur |Autor=Bettina Berger et al |Titel=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study |Hrsg= |Sammelwerk=Nutrition |Band=86 |Nummer= |Auflage= |Verlag= |Ort= |Datum=2021 |ISBN= |DOI=10.1016/j.nut.2021.111169 |Seiten=}}}} | | {{Infobox Studie|Name=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study|Publikation={{Literatur |Autor=Bettina Berger et al |Titel=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study |Hrsg= |Sammelwerk=Nutrition |Band=86 |Nummer= |Auflage= |Verlag= |Ort= |Datum=2021 |ISBN= |DOI=10.1016/j.nut.2021.111169 |Seiten=}}}} |
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− | '''Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study'''. Diese Studie untersucht die Möglichkeit des Fastens bei Typ-1 Diabetes.<ref>{{Literatur |Autor=Bettina Berger et al |Titel=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study |Hrsg= |Sammelwerk=Nutrition |Band=86 |Nummer= |Auflage= |Verlag= |Ort= |Datum=2021 |ISBN= |DOI=10.1016/j.nut.2021.111169 |Seiten=}}</ref> Federführend ist [[Bettina Berger]]. Die Studie gewann den [[Holzschuh-Preis für Komplementärmedizin|Holzschuh-Preis]] 2021. | + | '''Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study'''. Diese Studie untersucht die Möglichkeit des Fastens bei [[Wikipedia:Typ-1 Diabetes|Typ-1 Diabetes]].<ref>{{Literatur |Autor=Bettina Berger et al |Titel=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study |Hrsg= |Sammelwerk=Nutrition |Band=86 |Nummer= |Auflage= |Verlag= |Ort= |Datum=2021 |ISBN= |DOI=10.1016/j.nut.2021.111169 |Seiten=}}</ref> Federführend war [[Bettina Berger]]. Die Studie gewann den [[Holzschuh-Preis für Komplementärmedizin|Holzschuh-Preis]] 2021. |
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− | == Abstract == | + | ==Abstract== |
| + | |
| + | === Objectives === |
| + | Intermittent as well as prolonged fasting are receiving considerable attention and appear favorable in conditions such as metabolic syndrome, type 2 diabetes, and rheumatic diseases. Fasting for individuals with type 1 diabetes (T1D) is generally considered too risky. However, the ability and possibility to change from carbohydrate- to ketone-based fuel supply might be relevant for individuals with T1D. The aim of this patient-led research was to investigate the feasibility, benefit, and safety of a 7-d multimodal fasting intervention in individuals with T1D. |
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| + | === Methods === |
| + | This was a non-randomized controlled pilot study, with 20 participants with T1D and 10 without the disease. Data acquisition took place before, after, and 4 mo after the intervention and daily during intervention. |
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| + | === Results === |
| + | Of the individuals with T1D, 19 finished fasting. A mean β-hydroxybutyrate as representative ketone body increased to 2.8 ± 1.9 mmol/L on day 7; whereas average glucose remained between 4.9 (±1.5) and 7.5 (±2.3) mmol/L (89 ± 27 and 136 ± 40 mg/dL). Mean daily insulin dose was adjusted from 24.4 (3–50) IU on the day before fasting to 7.6 (0–26.7) IU on day 7. Quality of life (WHO-5) normalized from 54 (±4.4) to 68.8 (±15; ''P'' = 0.01) after fasting. There was a decrease from before until the follow-up 4 mo later of weight from 77.6 (±20.4) to 76.6 (±20.9) kg (''P'' = 0.023) and for body mass index from 27.68 (±7.04) to 26.74 (±7.15) kg/m<sup>2</sup> (''P'' = 0.008). Diastolic blood pressure increased from 69.75 (±11.41) to 75.74 (±8.42) mm Hg (''P'' = 0.028) and stayed in a healthy range on average. Fasting-related side effects were all temporary, and slightly more prevalent in those with type 1 diabetes compared with the reference group. |
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| + | === Conclusions === |
| + | This study demonstrated the feasibility, benefits, and safety aspects of a 7-d fast in adults with T1D. |
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| ==Einzelnachweise== | | ==Einzelnachweise== |
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| [[Kategorie:Fasten]] | | [[Kategorie:Fasten]] |
| [[Kategorie:Diabetes Typ I]] | | [[Kategorie:Diabetes Typ I]] |
| + | [[Kategorie:Kontrollierte Studie]] |
| + | [[Kategorie:Pilotstudie]] |
| + | [[Kategorie:Machbarkeitsstudie]] |