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− | {{Infobox Studie|Name=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study|Publikation={{Literatur |Autor=Bettina Berger et al |Titel=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study |Hrsg= |Sammelwerk=Nutrition |Band=86 |Nummer= |Auflage= |Verlag= |Ort= |Datum=2021 |ISBN= |DOI=10.1016/j.nut.2021.111169 |Seiten=}}}} | + | {{Infobox Studie|Name=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study|Publikation=Studienprotokoll<ref name=":1" />, <ref name=":0" />|Abkürzung=FaMeD1|Status=Abgeschlossen|Website=https://www.uni-wh.de/gkls/forschung/projekte/integrative-typ-1-diabetologie/|Personen=Wissenschaftliche Studienleitung: [[Bettina Berger]]}} |
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− | '''Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study'''. Diese Studie untersucht die Möglichkeit des Fastens bei [[Wikipedia:Typ-1 Diabetes|Typ-1 Diabetes]].<ref>{{Literatur |Autor=Bettina Berger et al |Titel=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study |Hrsg= |Sammelwerk=Nutrition |Band=86 |Nummer= |Auflage= |Verlag= |Ort= |Datum=2021 |ISBN= |DOI=10.1016/j.nut.2021.111169 |Seiten=}}</ref> Federführend war [[Bettina Berger]]. Die Studie gewann den [[Holzschuh-Preis für Komplementärmedizin|Holzschuh-Preis]] 2021. | + | '''Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study'''. Diese Studie untersucht die Machbarkeit und Sicherheit einer [[Buchinger Fasten|Buchinger-Fastenintervention]] bei Menschen mit [[Wikipedia:Typ-1 Diabetes|Typ-1-Diabetes mellitus]]<ref name=":0">{{Literatur |Autor=Bettina Berger et al |Titel=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study |Hrsg= |Sammelwerk=Nutrition |Band=86 |Nummer= |Auflage= |Verlag= |Ort= |Datum=2021 |ISBN= |DOI=10.1016/j.nut.2021.111169 |Seiten=}}</ref> in Hinblick auf diabetesbezogene Problembereiche und unerwünschte Ereignisse wie [[Wikipedia:Ketoazidose|Ketoazidosen]] und schwere [[Wikipedia:Hypoglykämie|Unterzuckerungen]].<ref name=":1" /> Dazu [[Fasten|fasteten]] 20 Personen mit und eine Referenzgruppe von 10 Personen ohne Diabetes sieben Tage nach dem [[Buchinger Fasten|Buchinger-Programm]].<ref name=":2">{{Internetquelle |autor=Kay Gropp (Pressestelle Universität Witten/Herdecke) |url=https://idw-online.de/de/news783250 |titel=Holzschuh-Preis für Studie: Fasten ist auch mit Typ 1 Diabetes möglich |werk=idw |hrsg= |datum=2021-11-30 |abruf=2021-12-30 |sprache=}}</ref> Die Blutzuckerwerte blieben überwiegend im Zielbereich; schwere Hypo- oder Hyperglykämien traten nicht auf. Signifikant verbessert haben sich sowohl direkt nach dem Fasten als auch in einem Nacherhebung das Gewicht und der [[Wikipedia:Body-Mass-Index|BMI]]. In der qualitativen Befragung 4 Monate nach der Intervention konnten neben den physischen Verbesserungen deutliche Änderungen im Diabetes-Management festgestellt werden: eine gesteigerte Flexibilität im Umgang mit Essensvorschriften und die Entwicklung der Fähigkeit zum [[Wikipedia:Intermittierendes Fasten|intermittierenden Fasten]].<ref name=":2" /> |
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− | ==Abstract== | + | Die wissenschaftliche Studienleitung hatte [[Bettina Berger]] inne. Die Studie gewann den [[Holzschuh-Preis für Komplementärmedizin|Holzschuh-Preis]] 2021.<ref name=":2" /> |
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− | === Objectives === | + | ==Abstract<ref name=":0" />== |
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| + | ===Objectives=== |
| Intermittent as well as prolonged fasting are receiving considerable attention and appear favorable in conditions such as metabolic syndrome, type 2 diabetes, and rheumatic diseases. Fasting for individuals with type 1 diabetes (T1D) is generally considered too risky. However, the ability and possibility to change from carbohydrate- to ketone-based fuel supply might be relevant for individuals with T1D. The aim of this patient-led research was to investigate the feasibility, benefit, and safety of a 7-d multimodal fasting intervention in individuals with T1D. | | Intermittent as well as prolonged fasting are receiving considerable attention and appear favorable in conditions such as metabolic syndrome, type 2 diabetes, and rheumatic diseases. Fasting for individuals with type 1 diabetes (T1D) is generally considered too risky. However, the ability and possibility to change from carbohydrate- to ketone-based fuel supply might be relevant for individuals with T1D. The aim of this patient-led research was to investigate the feasibility, benefit, and safety of a 7-d multimodal fasting intervention in individuals with T1D. |
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− | === Methods === | + | ===Methods=== |
| This was a non-randomized controlled pilot study, with 20 participants with T1D and 10 without the disease. Data acquisition took place before, after, and 4 mo after the intervention and daily during intervention. | | This was a non-randomized controlled pilot study, with 20 participants with T1D and 10 without the disease. Data acquisition took place before, after, and 4 mo after the intervention and daily during intervention. |
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− | === Results === | + | ===Results=== |
| Of the individuals with T1D, 19 finished fasting. A mean β-hydroxybutyrate as representative ketone body increased to 2.8 ± 1.9 mmol/L on day 7; whereas average glucose remained between 4.9 (±1.5) and 7.5 (±2.3) mmol/L (89 ± 27 and 136 ± 40 mg/dL). Mean daily insulin dose was adjusted from 24.4 (3–50) IU on the day before fasting to 7.6 (0–26.7) IU on day 7. Quality of life (WHO-5) normalized from 54 (±4.4) to 68.8 (±15; ''P'' = 0.01) after fasting. There was a decrease from before until the follow-up 4 mo later of weight from 77.6 (±20.4) to 76.6 (±20.9) kg (''P'' = 0.023) and for body mass index from 27.68 (±7.04) to 26.74 (±7.15) kg/m<sup>2</sup> (''P'' = 0.008). Diastolic blood pressure increased from 69.75 (±11.41) to 75.74 (±8.42) mm Hg (''P'' = 0.028) and stayed in a healthy range on average. Fasting-related side effects were all temporary, and slightly more prevalent in those with type 1 diabetes compared with the reference group. | | Of the individuals with T1D, 19 finished fasting. A mean β-hydroxybutyrate as representative ketone body increased to 2.8 ± 1.9 mmol/L on day 7; whereas average glucose remained between 4.9 (±1.5) and 7.5 (±2.3) mmol/L (89 ± 27 and 136 ± 40 mg/dL). Mean daily insulin dose was adjusted from 24.4 (3–50) IU on the day before fasting to 7.6 (0–26.7) IU on day 7. Quality of life (WHO-5) normalized from 54 (±4.4) to 68.8 (±15; ''P'' = 0.01) after fasting. There was a decrease from before until the follow-up 4 mo later of weight from 77.6 (±20.4) to 76.6 (±20.9) kg (''P'' = 0.023) and for body mass index from 27.68 (±7.04) to 26.74 (±7.15) kg/m<sup>2</sup> (''P'' = 0.008). Diastolic blood pressure increased from 69.75 (±11.41) to 75.74 (±8.42) mm Hg (''P'' = 0.028) and stayed in a healthy range on average. Fasting-related side effects were all temporary, and slightly more prevalent in those with type 1 diabetes compared with the reference group. |
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− | === Conclusions === | + | ===Conclusions=== |
| This study demonstrated the feasibility, benefits, and safety aspects of a 7-d fast in adults with T1D. | | This study demonstrated the feasibility, benefits, and safety aspects of a 7-d fast in adults with T1D. |
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| + | ==Weblinks== |
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| + | *Video: Präsentation der Machbarkeitsstudie (für den ECIM 2021/in englischer Sprache) - https://www.hufelandgesellschaft.de/fileadmin/Videos/Berger-ECIM2021%20.mp4 |
| + | *Video: Präsentation der Machbarkeitsstudie (für die Preisverleihung/in deutscher Sprache) - https://www.hufelandgesellschaft.de/fileadmin/Videos/Berger%20et%20al_FastenBeiDiabetesTyp1.mp4 |
| + | *Dokumentarfilm zur Fastenstudie: https://www.youtube.com/watch?v=MLZz6XBipXk&t=6s |
| + | *Interview mit Bettina Berger: https://www.carstens-stiftung.de/artikel/dr-bettina-berger-fasten-fuer-menschen-mit-typ-1-diabetes.html |
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| + | ==Publikationen== |
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| + | *Studienprotokoll: {{Cite journal| issn = 1439-1635| volume = 34| issue = 02| pages = 74–81| last1 = Berger| first1 = Bettina| last2 = Stange| first2 = Rainer| last3 = Baumann| first3 = Andrea| last4 = Köblös| first4 = Diana| last5 = Liebscher| first5 = Daniela| last6 = Bley| first6 = Martina| last7 = Michalsen| first7 = Andreas| last8 = Martin| first8 = David| title = Fasten für Menschen mit Typ-1-Diabetes (FaMeD1)| journal = Ernährung & Medizin| date = 2019-06-17|doi=10.1055/a-0831-6231}}<ref name=":1">{{Cite journal|issn=1439-1635|volume=34|issue=02|pages=74–81|last1=Berger|first1=Bettina|last2=Stange|first2=Rainer|last3=Baumann|first |
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| + | 3=Andrea|last4=Köblös|first4=Diana|last5=Liebscher|first5=Daniela|last6=Bley|first6=Martina|last7=Michalsen|first7=Andreas|last8=Martin|first8=David|title=Fasten für Menschen mit Typ-1-Diabetes (FaMeD1)|journal=Ernährung & Medizin|date=2019-06-17|doi=10.1055/a-0831-6231}}</ref> |
| + | *{{Literatur |Autor=Bettina Berger et al |Titel=Seven-day fasting as a multimodal complex intervention for adults with type 1 diabetes: Feasibility, benefit and safety in a controlled pilot study |Hrsg= |Sammelwerk=Nutrition |Band=86 |Nummer= |Auflage= |Verlag= |Ort= |Datum=2021 |ISBN= |DOI=10.1016/j.nut.2021.111169 |Seiten=}}<ref name=":0" /> |
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| ==Einzelnachweise== | | ==Einzelnachweise== |
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| [[Kategorie:Pilotstudie]] | | [[Kategorie:Pilotstudie]] |
| [[Kategorie:Machbarkeitsstudie]] | | [[Kategorie:Machbarkeitsstudie]] |
| + | [[Kategorie:Studie]] |